Leukotrienes are potent inflammatory mediators, by acting on the cell membrane of the leukotriene receptor play a role, can cause bronchospa
Leukotrienes are potent inflammatory mediators, by acting on the cell membrane of the leukotriene receptor play a role, can cause bronchospasm, increased airway hyperresponsiveness, increased mucus secretion, increased mucosal edema, promoting the proliferation of airway smooth muscle in the pathogenesis of asthma, plays an important role.
Clinical studies have found that patients with leukotriene levels in patients with dysmenorrhea and menstrual period of asthma was significantly increased. Leukotriene receptor antagonists, such as montelukast (Shun Erning), on three ene receptor with high affinity, can effectively inhibit the effect of leukotrienes. It can improve airway function, improve symptoms and quality of life in patients with dysmenorrhea and asthma. Although glucocorticoids are one of the most potent anti-inflammatory drugs available today, it does not inhibit the inflammatory response in asthma,
Therefore, to control the application of inhaled corticosteroids and leukotriene modifiers can improve asthma in dysmenorrhea and menstrual period in the treatment of asthma.
See also: Jiang Lei Dai, Yin Kaisheng, Sun Lizhou. Progress in the diagnosis and treatment of asthma in peri - menstrual cycle. Chinese Journal of asthma (electronic version), 2010,4:150-152
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