According to the statistics of the WHO, mood disorders such as depression affects about 10% of the world's population, many scientists aroun
According to the statistics of the WHO, mood disorders such as depression affects about 10% of the world's population, many scientists around the world in the understanding of these diseases put a lot of effort, however, the molecular and cellular mechanisms underlying mental disorders still only get some understanding.
The existing antidepressants are not good enough: 60-70% patients did not receive any help for other 30-40% patients, the disease is often not completely help, they must be obtained before any effect of drugs for a long time. In addition, some drugs have many side effects associated with drugs. Therefore, it is clear that new and better drugs are needed, and the first is to better understand the disease process.
Recently, to study the molecular mechanism of brain serotonin system Orna Issler Weizmann Institute professor Alon Chen and his doctoral students which, when serotonin system disorders, the development of its participation in the depression and anxiety. Chen and his colleagues investigated the role of microRNA molecules in the production of serotonergic nerve cells. The study was published in the Journal Neuron.
The scientists point out that serotonin, a nerve cell in the brain, increases levels of miR135 when given antidepressants. Mice were genetically modified to produce an average of more than miR135, and the results were more resistant to constant stress, and mice did not receive any chronic stress related behaviors such as anxiety or depression.
In contrast, miR135 mice showed lower levels of these behaviors; in addition, the response of mice to antidepressants was weak. In other words, the brain needs an appropriate level of miR135, miR135 levels are low, but enough to ensure a healthy response to stress, miR135 levels are high enough to avoid depression or anxiety disorders.
When tested on human blood samples, the researchers found that subjects with depression had abnormally low levels of miR135 in their blood. The scientists found that the 3 genes involved in miR135 are located in the genome region known to be bipolar affective disorder. These results suggest that miR135 may be a potential therapeutic molecule.
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