Chronic pain genetic?

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Genetic factors can explain the differences in behavior, psychology, cognition and physiological process to a great extent. However, it may


Genetic factors can explain the differences in behavior, psychology, cognition and physiological process to a great extent. However, it may not be easy to analyze the impact of genetic factors on pain sensitivity, since this effect is likely to be the result of the interaction of multiple genes and the environment

Why are women more sensitive than men? Mothers may have to better protect their children, they must be more sensitive to pain. Not only do men produce morphine like proteins, but they are also more sensitive to this type of protein than women. For example, if a doctor needs to inject such a protein into a patient, a woman needs a dose greater than men, because women are less sensitive to the protein than men.

The patient's sensitivity to pain is not limited to gender differences. Scientists have long known that people with white skin and red hair tend to be more sensitive to pain, and they need a bigger dose of painkillers. In early 80s, scientists found that ten percent of Caucasians are lack of a gene, this gene mainly produces a let patients can absorb painkillers codeine enzyme. So, give them useless and codeine injection, after injection there will be side effects. Scientists have also found that genetic factors can determine whether sedative SSRIs acts on patients.

Human sensitivity to pain is not solely determined by a single gene. In the Mogil trial, he found that people who tested mice also had an impact on the results. When he did the experiment himself, he recorded a short time. But when his students did the experiment, the rats were generally more responsive.

There are gender differences in pain, and other aspects, such as race, are still controversial. The estimation of genetic effects is the role of a single gene in pain, and we have gained a lot of information in this regard. According to the results of animal experiments, 24% of the thermal hyperalgesia was determined by heredity. Analysis of the similarity between brothers and sisters can understand the proportion of different parts of the genetic characteristics of the experimental cold pain and heat pain between the value of 0.11-0.23. Compared with the pain model, the genetic predisposition of clinical pain was more obvious, such as migraine (50% hereditary), dysmenorrhea (55%), low back pain and neck pain (35-68%), shoulder and elbow pain (50%), carpal tunnel syndrome (), etc..

Pain is the result of interaction between gene and environment. It has a lot to do with the genes and growth processes. The doctor will not simply tell the patient: "take two painkillers, see me in the morning."

Pharmacological genetics is the study of individual differences in drug response in gene expression. For example, the genes encoding P4502D6 (a specific cytochrome P450 enzyme) are highly polymorphic in the population. Cytochrome P450 enzyme family is a multi gene, such as tricyclic antidepressants, tramadol, codeine, dextromethorphan metabolism which involved a variety of drugs. P4502D6 can make the in vivo metabolism of morphine and codeine exert analgesic effect, if the gene mutation and inactivation result, will lose the analgesic effect of codeine.

Another variant of the P4502D6 gene is gene amplification. Some people have 13 copies of the P4502D6 chromosome gene, in sequence, this amplification leads to accelerated the metabolism of codeine, the treatment effect of abnormal short. We compared the daily dose of a dose of Mg for patients with drug metabolic disorder to 10-20 mg, and for patients with gene amplification, the required daily dose of a dose of 500 mg / l..

The study of the mechanism of pain may provide a new target for the development of new analgesics. The development of analgesic drugs is commonly used to produce or modulate the pain of a single protein molecules, cytokines or neurotransmitters. In addition, high yield mRNA screening can also be used. It has been found that the expression of hundreds of genes in inflammatory sensory neurons has changed, including some of the less common genes in the nervous system.


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