Hunan University of Chinese MedicineProfessor Wang Ruoguang, Doctoral Tutor (medical doctor, postdoctoral Biology)Introduction: insulin resi
Hunan University of Chinese Medicine
Professor Wang Ruoguang, Doctoral Tutor (medical doctor, postdoctoral Biology)
Introduction: insulin resistance (resistance, insulin, resistance; IR) for obstetrics and gynecology doctors, are not strange, because this mechanism with polycystic ovary syndrome (polycystic ovarian, syndrome, PCOS) is directly related to. PCOS can act as insulin resistance, hyperinsulinemia Kaohsiung hormones, because of the complexity of the pathogenesis of IR and its aftermath, the associated with a series of performance together, also called insulin resistance syndrome (insulin resistance syndromeIRS).
Insulin resistance (resistance, insulin resistance; IR): refers to the effect of insulin to perform its normal biological function, manifested as peripheral tissueespecially muscle, using the rate of glucose in adipose tissue, early islet beta cells can compensatory increase in insulin secretion for lack of effect, but in the course of time, islet beta cell the function will be gradually weakened, resulting in impaired glucose tolerance and diabetes.
Research shows that in many risk factors of cardiovascular disease in insulin resistance is the core, or that insulin resistance is a variety of diseases, especially the common risk factor of diabetes and cardiovascular disease, is a common soil breed related variety of metabolism. A large number of epidemiological data show that insulin resistance in diabetes and cardiovascular disease before the onset of many years, often associated with obesity, age, hypertension, hyperlipidemia, accompanied by. At present, insulin resistance, central obesity, impaired glucose tolerance or diabetes, hypertension, dyslipidemia and other diseases, collectively known as metabolic syndrome or insulin resistance syndrome. Therefore, insulin resistance is an important reason for the development of diabetes, hypertension, hyperlipidemia and other diseases.
1 insulin resistance and hypertension
In the early stage of insulin resistance and hyperinsulinemia by affecting the sympathetic activity, increased heart rate, so as to promote the proliferation of small arterioles, the pressor substance sensitivity enhancement, in the course of time on the formation of hypertension.
2 insulin resistance and diabetes
The insulin resistance in late islet function failure, can not produce normal amounts of insulin, causes the blood sugar is out of control, have diabetes, the study confirmed that insulin resistance is the main pathogenesis of type 2 diabetes.
After the onset of diabetes, lipid metabolism disorders, blood pressure and further increase. Therefore, hypertension and diabetes are related to each other, the impact of a pair of brothers in trouble, can not be separated from each other, the division of the diagnosis and treatment. High blood pressure, diabetes and other fuel, making people have the possibility of myocardial infarction or cerebral infarction doubled.
3 insulin resistance and obesity
In patients with type 2 diabetes for obesity is a well-known fact. This is because metabolic disorders in patients with type 2 diabetes may increase insulin resistance. Generally speaking, high blood lipid levels in human obesity, and more for abdominal obesity (fat on belly), which will promote insulin resistance and insulin resistance in turn will aggravate the metabolic disorder, which formed a vicious spiral.
4 insulin resistance and hyperlipidemia
In the presence of insulin resistance, the normal physiological activity of the liver was affected, and the synthesis of free fatty acid and triglyceride increased. Free fatty acids and triglycerides can reduce insulin sensitivity, which suggests that insulin resistance is closely related to dyslipidemia.
5 insulin resistance and coronary heart disease
More and more studies show that insulin resistance is one of the risk factors of coronary heart disease. Confirmed that the pathogenesis of coronary heart disease, there is the relationship between insulin resistance and vascular injury, lipid metabolism disorders, which greatly increases the chance of coronary atherosclerosis in patients with coronary heart disease and insulin resistance, the incidence rate increased significantly.
6 insulin resistance and polycystic ovary syndrome
Insulin receptor gene mutation or in a higher - "peptide receptor tyrosine kinase activity, decreased serum insulin level increased" - "effect increased assimilation strengthening -" induced by LH in ovarian stromal hyperplasia - "-" increased androgen synthesis of insulin and insulin growth factor (IGF-1) - "thecal androgen increase increased synthesis of -" ovarian aromatase system (decreased activity of cytochrome P450) - "the internal aromatization activity to reduce ovarian androgen to estrogen -" ability - "Kaohsiung hormones.
Hyperinsulinemia leads to a decrease in plasma sex hormone binding protein - an increase in free androgen.
So as to form a series of pathophysiological features and regularity of PCOS and its complications. For additional information about the pathophysiology and regularity of PCOS and the personal views of the diagnosis and treatment, please read my other related articles.
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