The tumor almost never shared the same genetic mutation, the fact that people will be arranged for better cancer types, and develop more eff
The tumor almost never shared the same genetic mutation, the fact that people will be arranged for better cancer types, and develop more effective targeted therapy into scientific efforts to face difficulties.
In the September 15th issue of the "natural method" (Nature Methods) this new research papers in the journal, researchers from University of California at San Diego proposed a hierarchical network based on call (network-based stratification, NBS) of the new method, this method is not based on the mutations of individual patients, but according to these mutations affect genetic network or sharing system to identify cancer subtypes.
"Typing is the most fundamental step toward personalized care," said Dr. Trey Ideker, head of the genetics department at the University of Santiago medical school in California. According to the data of the patients, the patients were classified into subtypes related to treatment. For example, a subtype of cancer is known to respond well to the drug A, which does not respond well to drug B. Without typing, each patient will look the same, and you will not think of how to treat them differently.
In recent years, advances in scientific knowledge and technology have made it easier and cheaper to sequence individual genomes, especially in cancer therapy. Fundamentally, cancer is a genetic disease.
But the gene "is very diverse," says Ideker. Mutations are combined to cause diseases such as cancer, which are affected by other factors. Each patient's cancer is genetically unique and can affect the efficacy and outcome of clinical treatment.
"When you look at patient data at the genetic level, everyone looks different. But when you look at the biological networks and systems that are affected, the typing becomes apparent. There is no mutation in exactly the same place, but some of the mutations occur in the same genetic pathway, "Ideker said.
The Cancer Genome Atlas (Cancer Genome Atlas) is an ongoing project by the National Institutes of health funding, to collect and catalog tens of thousands of genome of cancer patients. In patients with lung cancer, uterine cancer, and ovarian cancer, compiled by the Cancer Genome Atlas, the scientists looked specifically at somatic mutations that are present in tumors but not in healthy tissues.
The NBS method has a direct clinical value, Ideker said. Genome sequencing for cancer patients is rapidly becoming an integral part of standard diagnosis. Clinicians can use NBS to better match treatment with cancer subtypes. By recording the results of cancer, and these results are concentrated into the database, they can further improve and improve cancer treatment, tailored for the individual treatment of patients
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