Hepatitis B self-management recommendations at different ages

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Hepatitis B virus infection is a common disease in our country, and is the most common cause of liver cirrhosis and liver cancer. So far, Ch


Hepatitis B virus infection is a common disease in our country, and is the most common cause of liver cirrhosis and liver cancer. So far, China and the world there is no effective therapy against hepatitis B virus infection, current therapies including interferon A and lamivudine, adefovir, entecavir and telbivudine nucleoside (acid) class of oral drugs, but these drugs largely control the virus replication, to avoid virus replication leads to increased DNA caused by HBV the liver damage, thus to reduce or avoid the occurrence of liver cirrhosis and hepatocellular carcinoma. However, not all patients are suitable for the treatment of hepatitis B infection. So far the international view, only the index of liver function is abnormal, were abnormal and transaminase increased more than 2 times before they can be considered for treatment; of course, if the liver biopsy showed obvious liver inflammation, even normal transaminase can also be antiviral therapy.

The vast majority of our patients were hepatitis B in children infected with hepatitis B before, and teenagers and even adults infected with hepatitis B basically can appear ofhbsag, a few into "hepatitis", the general will not affect the body. For children infected with hepatitis B, with the development of the body, grow up, hepatitis B disease also experienced four stages of different characteristics:

Children period: the period of hepatitis B for the vast majority of the performance we usually say of chronic hepatitis B carriers (commonly known as hepatitis B carriers), these people are basically normal transaminase, do not need treatment, only need to be checked regularly, usually once every six months to check liver function, if liver function is normal, do not need special treatment; of course in this period, if found abnormal aminotransferase activity, especially transaminase of more than 100U/L, should be actively select the interferon a treatment to prevent progression of the disease, leading to cirrhosis and liver cancer.

Youth: hepatitis B disease during this period can be expressed as the It differs from man to man., repeated liver transaminases, called hepatitis; hepatitis B virus carriers can also be expressed as normal, liver transaminase. For repeated transaminase disorder, especially transaminase reached more than 200U/L, should be active antiviral therapy; due to lamivudine, adefovir, entecavir, telbivudine and other nucleoside (acid) oral drug treatment for a long time, during the period of treatment is strongly recommended to avoid becoming pregnant, because this period; and that the big three patients choose interferon if the treatment effect is poor, need further examination to evaluate the degree of liver damage, if the illness is lighter, can stop drug observation; if hepatic fibrosis is heavy, and even cirrhosis, should choose nucleoside drugs in the long course of treatment. If you need to monitor the normal transaminase, liver transaminase, since this period prone to transient hepatitis activity, so the monitoring period should be shortened to 3 months.

Middle age: in this period, hepatitis B disease can vary from asymptomatic HBV carriers to liver cirrhosis and hepatocellular carcinoma. During this period, most patients had active hepatitis and liver damage, which can easily diagnose hepatitis B virus carriers. If there were abnormal liver function, and the virus DNA higher than 100000 copies /mL, it should be actively treated; antiviral drugs during this period can choose interferon or nucleoside drugs treatment according to their own characteristics, needs to be emphasized is that patients with cirrhosis does not advocate interferon treatment, unless liver biopsy proved to belong to early liver cirrhosis. If the normal transaminase, but the virus DNA is high, it is necessary to do FibroScan liver hardness examination, liver biopsy when necessary to clear up the degree of liver injury, especially the "small Sanyang" hepatitis B patients, so as not to delay the disease diagnosis. Because about 40% of patients with cirrhosis have no signs or symptoms.

Old age: the majority of hepatitis B during this period has been in a stable state, a small number of cases have been developed to liver cirrhosis and even liver cancer. For the development of cirrhosis patients should be actively using lamivudine and adefovir and entecavir and telbivudine nucleoside (acid) long-term treatment of oral drug class.


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