Hepatitis B virus (HBV) infection is a global health problem. There are a total of 2 billion hepatitis B virus carriers in the world, of whi
Hepatitis B virus (HBV) infection is a global health problem. There are a total of 2 billion hepatitis B virus carriers in the world, of which about 360 million are chronic hepatitis B surface antigen (HBsAg) positive carriers. The development of hepatitis B can lead to liver failure, cirrhosis and liver cancer. At present, the most effective way to prevent hepatitis B is the hepatitis B vaccine in infancy, but its immune effectiveness after the baby is not 100%. It has been reported in the literature that children with chronic hepatitis B will still be infected after vaccination. The mechanism of the failure of infants after vaccination with hepatitis B vaccine is not fully understood. From Taiwan, New Taipei Mackay medical school Tzu-Wei Wu (Wu Ziwei), conducted a study, the results of the study published online in the latest period (2013 Jan) of the "Hepatology".
The study included 8733 high school students who were born in July 1987 and tested for hepatitis B surface antigen (HBsAg) and surface antibody (anti-HBs). The overall positive rates of HBsAg and anti-HBS were 1.9% and 48.3%., respectively, and the positive rate of HBsAg in patients receiving hepatitis B immunoglobulin (adjusted risk ratio: 15.63; 95% confidence interval: 10.99-22.22) (). There was a significant negative correlation between the hepatitis B virus vaccine dose and HBsAg positive rate among the students who did not receive hepatitis B immunoglobulin (HBIG). (P trend value is 0.011). Adjusted risk ratios were 1, 1.52 (95% confidence interval 0.91-2.53) and 2.85 (95% CI: 1.39-5.81) in the patients who received the hepatitis B vaccine at a dose of 4 and 1-2 times, respectively. HBIG positive rate and positive rate of HBsAg were significantly increased in patients receiving HBIG, if the positive rate of maternal hepatitis B e antigen was not enough.
1974 HBsAg- and anti-HBs negative students were vaccinated with hepatitis B vaccine. The blood anti-HBs counts were compared before and after enhancement. The titer of anti-HBs titer after vaccination was enhanced by 10. MIU/mL accounted for about 27.9% of the total number of vaccinated patients by <. Before inoculation with 1.0-9.9IU/mL, the titer of anti-HBs was stronger than that of pre enhanced antibody titer of <, and the number of 1 mIU/mL was significantly increased. (p< 0.0001)
The study concludes that the most important determinant of maternal positive HBsAg after 15 years of active immunization with hepatitis B vaccine in infants is maternal HBeAg positive. A considerable number of complete immunizations will lose immune memory to HBsAg.
Premature Ejaculation,Tumour,Hypertension,Depression,Tumour,Andrology Diseases,Tumour,Arthritis,Pain,Deaf,。 Cure999
Cure999 @ 2018