Study on Italy scholars in the D type HBV carriers in HBeAg negative and HBsAg positive, genotypes showed that quantitative detection of ser
Study on Italy scholars in the D type HBV carriers in HBeAg negative and HBsAg positive, genotypes showed that quantitative detection of serum HBsAg and HBV levels of DNA, which can identify active HBV carriers (Gastroenterology 2010139:483).
The study included 209 participants with a median follow-up of 29 months. The results showed that the level of HBsAg (62.12 IU/ml) in the inactive HBV carriers (n = 56) was significantly lower than that in the active carriers (n = 153, IU/ml = 3029). In the activity of the carriers, the low activity of (HBV DNA for < 20000 IU/ml) HBsAg level was significantly lower than that of high activity (HBV DNA = 20000 IU/ml), 883 IU/ml and 4233 IU/ml respectively. The ratio of log10 HBV DNA to HBsAg was significantly different in non active, low activity and high mobility carriers, 0.25, 0.49 and 2.06, respectively, and the patients with chronic hepatitis B were higher than those of patients with liver cirrhosis (respectively, 1.97 and 2.34).
HBsAg (1000 IU/ml) and HBV DNA (2000 IU/ml) the accuracy of single point detection in diagnosis of inactive carriers was 94.3%, the sensitivity was 91.1%, specificity was 95.4%, positive and negative predictive values were 87.9% and 96.7%.
The level of HBsAg in active carriers was relatively stable, and the number of non active carriers decreased (0.0120 log10 IU/ml and 0.0768 log10 IU/ml per year). 6 cases of non active carriers HBsAg clearance.
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