Human infection with syphilis will produce two kinds of antibodies: one is non-specific lipid antibodies, one is a specific anti Treponema p
Human infection with syphilis will produce two kinds of antibodies: one is non-specific lipid antibodies, one is a specific anti Treponema pallidum antibody (TP-Ab). The commonly used serological test of syphilis is mainly used to detect the two kinds of antibodies. RPR test is a test for the detection of lipid antibody. The change of antibody titer is positively correlated with the treatment of syphilis. It is suitable for the auxiliary diagnosis of curative effect, follow-up and recurrence, and the application of primary hospital. Also used for diagnosis of early syphilis and latent syphilis, but not sensitive to neurosyphilis. TPHA test is a test of Treponema pallidum antibody, the antibody appears early, late, even after a formal treatment, can still be detected, or even a lifetime detection. The change of the titer was not related to the activity of syphilis, and could not be used as an index to evaluate the curative effect and to determine the recurrence and reinfection. That is to say, the serological test of RPR and the TPHA test are not necessarily positive. There are two possibilities for this:
One stage syphilis, because infection is not a long time, in a few days in the beginning of hard chancre, syphilis only to the lymph nodes not to blood serum has yet to produce antibodies or antibody content is less, the RPR test results were negative. However, if the dark field microscope to detect Treponema pallidum, combined with the history of contact and clinical symptoms of the diagnosis of syphilis. After hard chancre appears L-2 weeks, RPR test turned positive, TPHA positive than RPR at least 1 weeks later. Two patients with syphilis for a long time, the majority of syphilis serology test is positive, but there are also reported about 8% syphilis patients with negative RPR test.
Two patients with advanced syphilis, the general TPHA test was positive, but about 1/3 patients with negative RPR test. Therefore, when the diagnosis of syphilis, if single RPR test is easy to missed diagnosis. The diagnosis of syphilis should be based on the comprehensive analysis of the data of the contact history, physical examination, laboratory examination and Syphilis Serological test. Serological test of syphilis is an important basis for the diagnosis of syphilis, but not the only basis. If you recently had had feculent sex to contact history, external genital ulcers appeared or induration, should seek medical treatment as soon as possible, a serological negative test results can not easily exclude syphilis, should every L-2 weeks after repeated tests, to avoid misdiagnosis and delay the disease. If you have had a history of feculent sexual contact, when you suspect that you have syphilis, you should carry out two tests, RPR and TPHA.
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