In my daily clinical treatment asthenospermia oligospermia, pay special attention to indomethacin, also called indomethacin, were puzzled, t
In my daily clinical treatment asthenospermia oligospermia, pay special attention to indomethacin, also called indomethacin, were puzzled, the neighborhood hospital doctor scolded me proveharmful: This is one of the reasons I tell you now:
1, prostaglandin (PG) is widely distributed in various human tissues and body fluids, but with the highest concentration in seminal plasma, which is mainly composed of seminal vesicle secretion, is a class containing 20 carbon atoms of the unsaturated fatty acids, there are nine types, which has the most significant effect on the reproductive system of the PGE and PGF2 alpha. Low concentration of PG under normal circumstances have positive effect on sperm motility, but large doses of PG with antispermatogenic effect, vascular function, infection of testis, testicular blood flow reduction, can also cause pampiniform from testicular dysfunction, destruction of the heat exchange system, so that the temperature of the testes and accessory glands; can cause testicular weight decline spermatogenic cells, degeneration and loss, caused by degeneration of the sperm nucleus chromatin aggregation and release stimulated seminiferous myoid cell shrinkage; high dose of PG inhibited the spontaneous contraction of vas deferens, affect sperm transport.
The scientists found that using indomethacin (Xiao Yantong) and aspirin can reverse dyszoospermia caused by high concentration of PG, confirmed PG's anti sperm function.
2, patients with infertility due to reproductive system especially prostatitis and Vesiculitis epididymitis and produce a large number of PG, which have a great effect on spermatogenesis and sperm motility!
3, indomethacin as a potent inhibitor of prostaglandin, and prostaglandin negative effect on sperm production has been reported, and the clinical research of the author in 1999 in General Hospital of Nanjing Military Region, the experimental center of learning experience experiment showed that indomethacin sodium in vitro and clinical trials can promote the sperm count and the rate of increase of foreign experts after that indomethacin can also improve serum luteinizing hormone and follicle stimulating hormone LH FSH content, inhibit estrogen production more, is conducive to sperm production; improve the content of cyclic adenosine monophosphate cAMP in semen, is conducive to improve the vitality of sperm.
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